6-(2-amino-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid (3-trifluoromethyl phenyl)amide

Name	NVP-BAW2881
Synonyms	BAW2881 CS-2238 NVP-BAW2881 NVP-BAW-2881 NVP-BAW 2881 BAW2881 (NVP-BAW2881) 6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide 1-Naphthalenecarboxamide, 6-[(2-amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]- 6-(2-amino-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid (3-trifluoromethyl phenyl)amide
CAS	861875-60-7

Molecular Formula	C22H15F3N4O2
Molar Mass	424.38
Solubility	DMSO: ≥ 33 mg/mL
Storage Condition	-20℃
In vitro study	In vitro experiments showed that NVP-BAW2881 could inhibit the proliferation, migration and tubule formation of human umbilical vein endothelial cells and lymphatic endothelial cells.
In vivo study	NVP-BAW2881 can target the tyrosine kinase region of murine, porcine and human VEGFR2. It can be administered orally or topically, but has not been tested in humans. In vivo tests in VEGF-A transgenic mice, oral or topical NVP-BAW2881 administration reduced moss-like inflammation of the ear skin. The skin lesions of the treated mice had reduced leukocyte infiltration, reduced epidermal hyperplasia, normal Epidermal Keratinocyte differentiation, and fewer vascular abnormalities. The blood vessels of the NVP-BAW2881-treated mice became smaller and less numerous. Compared with the control group, the ear swelling, skin inflammation, lymph node enlargement and skin erythema of the mice in the experimental group were improved. While both routes of administration are effective (oral and topical), systemic administration is more potent than topical administration. Topical application of NVP-BAW2881 reduced VEGF-A-induced vascular permeability in mouse and domestic pig skin.

Last Update：2024-01-02 23:10:35

biological activity	BAW2881 (NVP-BAW2881) is a novel VEGFR tyrosine kinase inhibitor. At concentrations of 1.0-4.3 nM, PDGFRβ was effectively inhibited by VEGFR1-3; At concentrations of 45-72 nM, PDGFRβ was inhibited by c-Kit and RET (c-RET).
Target	Value
hVEGFR2 (Cell-free assay)	9 nM
C-Raf-1 (Cell-free assay)	24 nM
B-RAFV599E (Cell-free assay)	76 nM
c-Abl (Cell-free assay)	99 nM
mVEGF2 (Cell-free assay)	165 nM

Last Update：2024-04-09 19:05:17

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Product Name: NVP-BAW2881 Visit Supplier Webpage Request for quotation
CAS: 861875-60-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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6-(2-amino-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid (3-trifluoromethyl phenyl)amide Request for Quotation